Fatty acids help the brain

A study involving 99 healthy older adults found that levels of monounsaturated fatty acids were associated with cognitive performance and the organization of the brain's attention network.

MUFAs are found in olive oils, nuts and avocados, and are a component of the Mediterranean diet, which has been associated with slower cognitive decline and lower dementia risk.

The study found that general intelligence was associated with how efficiently the dorsal attention network was functionally organized used a measure called small-world propensity, which describes how well the neural network is connected within locally clustered regions as well as across globally integrated systems.

In turn, they found that those with higher levels of MUFAs in their blood had greater small-world propensity in their dorsal attention network, suggesting that this is part of the reason for the link between diet and cognition.

And in another study by the same researchers, involving 94 older adults (65-75), blood levels of three omega-3 fatty acids (ALA, stearidonic acid and ecosatrienoic acid) were associated with levels of fluid intelligence, and this was mediated by the size of the left frontoparietal cortex. A larger left frontoparietal cortex was associated with higher levels of the omega-3 acids and better performance on tests of fluid intelligence.

A second study found that the size of a brain region called the fornix was associated with a balance of omega-3 and omega-6 fatty acids in the blood, and a more robust fornix was linked to better memory. The fornix is one of the first brain regions to be compromised in Alzheimer's disease.

Reference: 

Zamroziewicz, M. K., Talukdar, M. T., Zwilling, C. E., & Barbey, A. K. (2017). Nutritional status, brain network organization, and general intelligence. NeuroImage, 161, 241–250. https://doi.org/10.1016/j.neuroimage.2017.08.043

Zamroziewicz Marta K.,Paul Erick J.,Zwilling Chris E., et al. Predictors of Memory in Healthy Aging: Polyunsaturated Fatty Acid Balance and Fornix White Matter Integrity[J]. Aging and disease, 2017, 8(4): 372-383. http://www.aginganddisease.org/EN/10.14336/AD.2017.0501

Related News

A study involving mice lacking a master clock gene called Bmal1 has found that as the mice aged, their brains showed patterns of damage similar to those seen in Alzheimer's disease and other neurodegenerative disorders. Many of the injuries seemed to be caused by free radicals.

A new study involving 96 older adults initially free of dementia at the time of enrollment, of whom 12 subsequently developed mild Alzheimer’s, has clarified three fundamental issues about Alzheimer's: where it starts, why it starts there, and how it spreads.

Analysis of 5715 cases from the National Alzheimer's Coordinating Center (NACC) database has found that nearly 80% of more than 4600 Alzheimer's disease patients showed some degree of vascular pathology, compared with 67% of the controls, and 66% in the Parkinson's group.

The jugular venous reflux (JVR) occurs when the pressure gradient reverses the direction of blood flow in the veins, causing blood to leak backwards into the brain.

The

Following on from the evidence that Alzheimer’s brains show higher levels of metals such as iron, copper, and zinc, a mouse study has found that amyloid plaques in Alzheimer’s-like brains with significant neurodegeneration have about 25% more copper than those with little neurodegeneration.

An Italian study has found that a significant percentage of Alzheimer’s patients suffer from Obstructive Sleep Apnea Syndrome. This respiratory disorder, which causes people to temporarily stop breathing during their sleep, affects cerebral blood flow, promoting cognitive decline.

Data from 70 older adults (average age 76) in the Baltimore Longitudinal Study of Aging has found that those who reported poorer sleep (shorter sleep duration and lower sleep quality) showed a greater buildup of amyloid-beta plaques.

A new discovery helps explain why the “Alzheimer’s gene” ApoE4 is such a risk factor.

Analyses of cerebrospinal fluid from 15 patients with Alzheimer's disease, 20 patients with mild cognitive impairment, and 21 control subjects, plus brain tissue from

Pages

Subscribe to Latest newsSubscribe to Latest newsSubscribe to Latest health newsSubscribe to Latest news